Relationship Between Traumatic Brain Injury and CJD
Statistical and mechanistic analysis of the TBI-CJD association
Key Findings
Population simulated
100,000
CJD incidence
1.5 per million/yr
Literature TBI-CJD cases
23
P(coincidence)
0.382
P(causal)
0.316
P(detection bias)
0.302
Min cohort for 80% power
>500,000
Bayesian Model Comparison
Power Analysis by Risk Ratio
CJD Rate by TBI Severity