Etiology of Sporadic Creutzfeldt-Jakob Disease

Bayesian model comparison of etiological hypotheses for sCJD

Key Results

Top hypothesisSpontaneous Misfolding
P(spontaneous)0.427
P(proteostasis)0.219
P(somatic mutation)0.197
Best multi-hit model3 hits
MM relative risk1.75x
sCJD incidence1.5/million/yr

Etiological Model Posteriors

Codon 129 Genotype Risk

Multi-Hit Model Comparison